Over 100 years ago medically unexplained pain (MUS or Hysteria) stimulated the development of modern psychology. Medically unexplained pain continues to challenge and confound sufferers and treating professionals alike. As the old adage ‘the body remembers’ reminds us, behind its “not me” stance and misdirected physical focus, chronic pain often conceals unresolved trauma and failed attempts to deal with vulnerability. Given its efficacy with trauma, EMDR presents as a promising approach. However, the unique characteristics of MUS (including physical pathology, somatic discomfort, somatoform dissociation, and health-related trauma) demand many modifications to the standard trauma protocol. More than ever EMDR treatment of pain/MUS requires a phased, integrative approach incorporating elements of psychodynamic, somatic, hypnotic and ego-state approaches.