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A treatment-response comparison study of resting-state functional magnetic resonance imaging between standard treatment of SSRI and standard treatment of SSRI plus non-dominant hand-writing task in patients with major depressive disorder (Frontiers in Psychiatry: Neuroimaging and Stimulation)

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Home / Resources / Depression / A treatment-response comparison study of resting-state functional magnetic resonance imaging between standard treatment of SSRI and standard treatment of SSRI plus non-dominant hand-writing task in patients with major depressive disorder (Frontiers in Psychiatry: Neuroimaging and Stimulation)

A treatment-response comparison study of resting-state functional magnetic resonance imaging between standard treatment of SSRI and standard treatment of SSRI plus non-dominant hand-writing task in patients with major depressive disorder

A non-dominant hand-writing exercise, developed with inspiration from EMDR , showed changes related with major depressive disorder treatment.


Article Abstract

“Background: Researches have recently shifted from functional/structural imaging studies to functional connectivity (FC) studies in major depressive disorder (MDD). We aimed to compare treatment response of two treatment groups before and after treatment, in terms of both with psychiatric evaluation scales and resting-state functional connectivity (RSFC) changes in order to objectively demonstrate the possible contribution of the non-dominant hand-writing exercise (NHE) effect on depression treatment.

Methods: A total of 26 patients who were right-handed women with similar sociodemographic characteristics were enrolled. Their pre-treatment resting-state functional magnetic resonance imaging (rs-fMRI) and neuropsychiatric tests were recorded, and then, patients were divided into two groups randomly. A standard treatment (ST) (fix sertraline 50 mg/day) was given to both groups. One randomly selected group was given the NHE in addition to the ST. After 8 weeks of treatment, all patients were reevaluated with rs-fMRI and neuropsychiatric tests. Pre- and post-treatment FC changes within the groups and post-treatment connectivity changes between groups were evaluated.

Results: Post-treatment neuropsychiatric tests were significantly different in both groups. Post-treatment, two brain regions’ connectivity changed in the ST group, whereas 10 brain regions’ connectivity changed significantly in the ST + NHE group. When treatment groups were compared with each other after the treatment, the FC of 13 regions changed in the ST + NHE group compared to the ST group (p-unc/p-PFD <0.05). The density of connectivity changes in the frontal and limbic regions, especially connectivities shown to change in depression treatment, in the ST + NHE group indicates a positive contribution to depression treatment, which is also supported by neuropsychiatric scale changes.

Conclusion: NHE, which we developed with inspiration from the Eye Movement Desensitization and Reprocessing (EMDR) method, showed significantly more connectivity changes related with MDD treatment. Beyond offering a new additional treatment method, our study will also contribute to the current literature with our efforts to evaluate all brain regions and networks that may be related to MDD and its treatment together, without being limited to a few regions.”

—Description from publisher

Article Access

Open Access

Kevser Boyraz, R., Kirpinar, I., Yilmaz, O., Ozyurt, O., Kilicarslan, T., & Aralasmak, A. (2021). A treatment-response comparison study of resting-state functional magnetic resonance imaging between standard treatment of SSRI and standard treatment of SSRI plus non-dominant hand-writing task in patients with major depressive disorder. Frontiers in Psychiatry: Neuroimaging and Stimulation, 698954. Open access: https://doi.org/10.3389/fpsyt.2021.698954 

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Basic Info Collapse

Date
September 2, 2021

Creator(s)
Rabia Kevser Boyraz, Ismet Kirpinar, Onur Yilmaz

Contributor(s)
Onur Özyurt, Tezer Kiliçarslan, Ayse Aralasmak

Topics
Depression

Practice & Methods
Neurobiology

More Info Collapse

Extent
14 pages

Publisher
Frontiers

Rights
Copyright © 2021 Boyraz, Kirpinar, Yilmaz, Özyurt, Kiliçarslan and Aralasmak. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

APA Citation
Kevser Boyraz, R., Kirpinar, I., Yilmaz, O., Ozyurt, O., Kilicarslan, T., & Aralasmak, A. (2021). A treatment-response comparison study of resting-state functional magnetic resonance imaging between standard treatment of SSRI and standard treatment of SSRI plus non-dominant hand-writing task in patients with major depressive disorder. Frontiers in Psychiatry: Neuroimaging and Stimulation, 698954. Open access: https://doi.org/10.3389/fpsyt.2021.698954

Audience
EMDR Therapists, Other Mental Health Professionals

Language
English

Content Type
Article, Peer-Reviewed

Access Type
External Resource, Open Access

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