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Trauma-focused psychotherapy response in youth with posttraumatic stress disorder is associated with changes in insula volume (Journal of Psychiatric Research)

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Home / Resources / PTSD / Trauma-focused psychotherapy response in youth with posttraumatic stress disorder is associated with changes in insula volume (Journal of Psychiatric Research)

Trauma-focused psychotherapy response in youth with posttraumatic stress disorder is associated with changes in insula volume

Study on the relationship between treatment response and alternations in brain structures associated with PTSD in children and adolescents.


Article Abstract

“Randomized controlled trials have shown efficacy of trauma-focused psychotherapies in youth with posttraumatic stress disorder (PTSD), but little is known about the relationship between treatment response and alternations in brain structures associated with PTSD. In this study, we longitudinally examined the association between treatment response and pre-to posttreatment changes in structural magnetic resonance imaging (MRI) scans using a voxel-based morphometry approach. We analyzed MRI scans of 35 patients (ages 8–18 years, 21 female) with PTSD (80%) or partial PTSD (20%) before and after eight weekly sessions of trauma-focused psychotherapy. PTSD severity was assessed longitudinally using the Clinician-Administered PTSD scale for Children and Adolescents to divide participants into responders and non-responders. Group by time interaction analysis showed significant differences in grey-matter volume in the bilateral insula due to volume reductions over time in non-responders compared to responders. Despite the significant group by time interaction, there were no significant group differences at baseline or follow-up. As typical development is associated with insula volume increase, these longitudinal MRI findings suggest that treatment non-response is associated with atypical neurodevelopment of the insula, which may underlie persistence of PTSD in youth. The absence of structural MRI changes in treatment responders, while in need of replication, suggest that successful trauma-focused psychotherapy may not directly normalize brain abnormalities associated with PTSD.”

—Description from publisher

Article Access

Open Access

Zantvoord, J. B., Zhutovsky, P., Ensink, J. B. M., Op den Kelder, R., van Wingen, G. A., & Lindauer, R. J. L. (2020). Trauma-focused psychotherapy response in youth with posttraumatic stress disorder is associated with changes in insula volume. Journal of Psychiatric Research. https://doi.org/10.1016/j.jpsychires.2020.10.037

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Basic Info Collapse

Date
January 1, 2021

Creator(s)
Jasper B. Zantvoord, Paul Zhutovsky, Judith B.M. Ensink

Contributor(s)
Rosanne Op den Kelder, Guido A. van Wingen, Ramon J.L. Lindauer

Topics
PTSD

Client Population
Adolescents, Children

Practice & Methods
Mechanisms of Action, Neurobiology

More Info Collapse

Extent
8 pages

Publisher
Elsevier

Rights
© 2020 The Author(s). Published by Elsevier Ltd.

APA Citation
Zantvoord, J. B., Zhutovsky, P., Ensink, J. B. M., Op den Kelder, R., van Wingen, G. A., & Lindauer, R. J. L. (2020). Trauma-focused psychotherapy response in youth with posttraumatic stress disorder is associated with changes in insula volume. Journal of Psychiatric Research. https://doi.org/10.1016/j.jpsychires.2020.10.037

Audience
EMDR Therapists, Other Mental Health Professionals

Language
English

Content Type
Article, Peer-Reviewed

Access Type
External Resource, Open Access

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