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Psychological and pharmacological interventions for posttraumatic stress disorder and comorbid mental health problems following complex traumatic events: Systematic review and component network meta-analysis (PLOS Medicine)

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Home / Resources / Complex Trauma/C-PTSD / Psychological and pharmacological interventions for posttraumatic stress disorder and comorbid mental health problems following complex traumatic events: Systematic review and component network meta-analysis (PLOS Medicine)

Psychological and pharmacological interventions for posttraumatic stress disorder and comorbid mental health problems following complex traumatic events: Systematic review and component network meta-analysis

This study provides a broad evidence base as a foundation to inform treatment guidelines and future research on complex trauma.


Article Abstract

“Background: Complex traumatic events associated with armed conflict, forcible displacement, childhood sexual abuse, and domestic violence are increasingly prevalent. People exposed to complex traumatic events are at risk of not only posttraumatic stress disorder (PTSD) but also other mental health comorbidities. Whereas evidence-based psychological and pharmacological treatments are effective for single-event PTSD, it is not known if people who have experienced complex traumatic events can benefit and tolerate these commonly available treatments. Furthermore, it is not known which components of psychological interventions are most effective for managing PTSD in this population. We performed a systematic review and component network meta-analysis to assess the effectiveness of psychological and pharmacological interventions for managing mental health problems in people exposed to complex traumatic events.

Conclusions: In this systematic review and meta-analysis, we observed that trauma-focused psychological interventions are effective for managing mental health problems and comorbidities in people exposed to complex trauma. Multicomponent interventions, which can include phase-based approaches, were the most effective treatment package for managing PTSD in complex trauma. Establishing optimal ways to deliver multicomponent psychological interventions for people exposed to complex traumatic events is a research and clinical priority.”

—Description from publisher

Article Access

Open Access

Coventry, P. A., Meader, N., Melton, H., Temple, M., Dale, H., Wright, K., Cloitre, M., Karatzias, T., Bisson, J., Roberts, N. P., Brown, J. V. E., Barbui, C., Churchill, R., Lovell, K., McMillan, D., & Gilbody, S. (2020). Psychological and pharmacological interventions for posttraumatic stress disorder and comorbid mental health problems following complex traumatic events: Systematic review and component network meta-analysis. PLOS Medicine, 1003262. Open access: https://doi.org/10.1371/journal.pmed.1003262

About the Journal

“PLoS ONE is an inclusive journal community working together to advance science by making all rigorous research accessible without barriers.”

—Description from publisher

 

View the Resource
Basic Info Collapse

Date
August 19, 2020

Creator(s)
Peter A. Coventry, Nick Meader, Hollie Melton

Contributor(s)
Melanie Temple, Holly Dale, Kath Wright, Marylène Cloitre, Thanos Karatzias, Jonathan Bisson, Neil P. Roberts, Jennifer V. E. Brown, Corrado Barbui, Rachel Churchill, Karina Lovell, Dean McMillan, Simon Gilbody

Topics
Complex Trauma/C-PTSD, PTSD

More Info Collapse

Extent
33 pages

Publisher
PLOS ONE

Rights
© 2020 Coventry et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

APA Citation
Coventry, P. A., Meader, N., Melton, H., Temple, M., Dale, H., Wright, K., Cloitre, M., Karatzias, T., Bisson, J., Roberts, N. P., Brown, J. V. E., Barbui, C., Churchill, R., Lovell, K., McMillan, D., & Gilbody, S. (2020). Psychological and pharmacological interventions for posttraumatic stress disorder and comorbid mental health problems following complex traumatic events: Systematic review and component network meta-analysis. PLOS Medicine, 1003262. Open access: https://doi.org/10.1371/journal.pmed.1003262

Audience
EMDR Therapists, Other Mental Health Professionals

Language
English

Content Type
Article, Meta-analyses/Systematic Reviews, Peer-Reviewed

Access Type
External Resource, Open Access

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Interventions for adults with a history of complex traumatic events: the INCiTE mixed-methods systematic review (Health Technology Assessment)

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Psychological interventions for pediatric posttraumatic stress disorder: A systematic review and network meta-analysis (JAMA Psychiatry)

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