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The effects of individual psychotherapy in BDNF levels of patients with mental disorders: A systematic review (Frontiers in Psychiatry)

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Home / Resources / Eating Disorders/Body Image / The effects of individual psychotherapy in BDNF levels of patients with mental disorders: A systematic review (Frontiers in Psychiatry)

The effects of individual psychotherapy in BDNF levels of patients with mental disorders: A systematic review

“A systematic review evaluating the effects of individual psychotherapy in BDNF levels in patients with mental disorders.”


Article Abstract

“Background: Brain-derived Neurotrophic Factor (BDNF) is considered the main cerebral neurotrophin and is produced in the central neural system and peripherals. Its levels are reduced in patients with several psychiatric disorders, but it is unclear if the response to psychotherapy can alter its concentration.

Objective: To carry out a systematic review evaluating the effects of individual psychotherapy in BDNF levels in patients with mental disorders.

Methods: The databases PubMed, EMBASE, PsycArticles, SciELO, Web of Science, and CENTRAL; the last search was performed on October 2019 for trials evaluating the effects of individual psychotherapy in BDNF levels in adults with mental disorders. PROSPERO registration: CRD42018108144.

Results: Eight of 293 studies were included. A rise in BDNF levels was observed in depressive patients when psychotherapy was combined with medication. Patients with post-traumatic stress disorder (PTSD) who responded to therapy presented a raise in BDNF levels mostly when combined with physical activity. There was a rise in BDNF levels in those who responded to psychotherapy in patients with bulimia, in borderline patients, and in insomniacs.

Conclusions: The BDNF seems to present variations after psychotherapy especially in patients with bulimia, PTSD, insomnia, and borderline. These subjects also have symptom reduction. Thereby, BDNF could be a supplemental tool to analyze the success to psychotherapy. BDNF levels in patients with major depression after therapy are still controversial and the short follow-up of most studies is a limiting factor.”

—Description from publisher

Article Access

Open Access 

Claudino, F. C. A., Goncalves, L., Schuch, F. B., Martins, H. R. S., & Rocha, N. S. D. (2020). The effects of individual psychotherapy in BDNF levels of patients with mental disorders: A systematic review. Frontiers in Psychiatry, 11:445. Open access: http://dx.doi.org/10.3389/fpsyt.2020.00445  

About the Journal

“Frontiers in Psychiatry is an interdisciplinary journal that focuses on translational and ‘bench-to-beside’ approaches to improve therapeutic options for mental illness and consequently to improve patient treatment outcomes.”

—Description from publisher

View the Resource
Basic Info Collapse

Date
May 18, 2020

Creator(s)
Felipe Cesar de Almeida Claudino, Leonardo Gonçalves, Felipe Barreto Schuch

Contributor(s)
Hugo Roberto Sampaio, Neusa Sica da Rocha

Topics
Eating Disorders/Body Image, PTSD

Practice & Methods
Mechanisms of Action, Neurobiology

More Info Collapse

Extent
9 pages

Publisher
Frontiers in Psychiatry

Rights
Copyright © 2020 Claudino, Gonçalves, Schuch, Martins and Rocha. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).

APA Citation
Claudino, F. C. A., Goncalves, L., Schuch, F. B., Martins, H. R. S., & Rocha, N. S. D. (2020). The effects of individual psychotherapy in BDNF levels of patients with mental disorders: A systematic review. Frontiers in Psychiatry, 11:445. Open access: http://dx.doi.org/10.3389/fpsyt.2020.00445  

Audience
EMDR Therapists, Other Mental Health Professionals

Content Type
Article, Meta-analyses/Systematic Reviews, Peer-Reviewed

Access Type
External Resource, Open Access

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